Ayurvedic Name: Guggulu
Botanical Name: Commiphora mukul
Common/English Name: Indian bedellium
Part(s) Used: Gum resin
Other Ingredients: Capsule (plant-derived Cellulose), Cellulose powder (plant-derived), Magnesium stearate, Silica.
This product is Gluten free. No artificial colors, preservatives or additives.
Serving Size: 1 Capsule
Servings Per Container: 60
Amount per serving
Guggul** (Commiphora mukul) 500 mg*
(Gum resin extract, standardized for 25 mg Guggulsterols incl.Type E & Z)
*Daily value not established
Other ingredients: Capsule (plant-derived Cellulose), Potato starch powder.
Individuals of dominant Kapha Dosha are susceptible to imbalances of their cholesterol levels. This is partially due to their slower metabolism.
Kaphas should start a regimented exercise program and minimize oily, heavy foods.
Joint conditions are an expected imbalance due to a Vata dominant person being more mobile and active than other Dosha types. Vata dominant individuals should seek less joint stressing activities. Swimming may be an alternative to running. Walking may be preferred over high impact aerobics. Adding regular body massage would be very helpful to Vata types.
Clinical Research Links
Partial List of Clinical Studies and articles: (Click on the name of the study to read more at “The National Library of Medicine”)
Guggul for hyperlipidemia: a review by the Natural Standard Research Collaboration. Ulbricht C, Basch E, Szapary P, Hammerness P, Axentsev S, Boon H, Kroll D, Garraway L, Vora M, Woods J; Natural Standard Research Collaboration. Complement Ther Med. 2005 Dec;13(4):279-90. Epub 2005 Sep 23.
The hypolipidemic natural product Commiphora mukul and its component guggulsterone inhibit oxidative modification of LDL. Wang X, Greilberger J. et. al.Atheroclerosis. 2004 Feb; 172(2):239-46
Herbs for serum cholesterol reduction: a systematic view. Thompson Coon JS, Ernst E.J Fam Pract. 2003 Jun;52(6):468-78.
GUGULIPID: a natural cholesterol-lowering agent. Yokozawa T., et al. Br J Nutr 2007 Jun; 97(6): 1187-95
The hypolipidemic natural product guggulsterone is a promiscuous steroid receptor ligand. Burris TP, Montrose C. et. al. Mol Pharmacol. 2005 MAr; 67(3):948-54
Therapeutic effects of Guggul and its constituent guggulsterone: cardiovascular benefits. Deng R.Cardiovasc Drug Rev. 2007 Winter; 25(4):375-90
A natural product that lowers cholesterol as an antagonist ligand for FXR. Urizar NL, Liverman AB, Dodds DT, Silva FV, Ordentlich P, Yan Y, Gonzalez FJ, Heyman RA, Mangelsdorf DJ, Moore DD. Science. 2002 May 31;296(5573):1703-6. Epub 2002 May 2
Bioactive terpenoids and guggulusteroids from Commiphora mukul gum resin of potential anti-inflammatory interest. Ganju L, Karan D, Chanda S, Srivastava KK, Sawhney RC, Selvamurthy W. Biomed Pharmacother. 2003 Sep;57(7):296-300.
Is antagonism of E/Z-guggulsterone at the farnesoid X receptor mediated by a noncanonical binding site? A molecular modeling study.Meyer U, Costantino G, Macchiarulo A, Pellicciari R. J Med Chem. 2005 Nov 3;48(22):6948-55.
Guggulu (Commiphora mukul) potentially ameliorates hypothyroidism in female mice. Panda S, Kar A. Phytother Res. 2005 Jan;19(1):78-80.
Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis. Shishodia S, Aggarwal BB. J Biol Chem. 2004 Nov 5;279(45):47148-58. Epub 2004 Aug 17
The hypolipidemic natural product Commiphora mukul and its component guggulsterone inhibit oxidative modification of LDL. Wang X, Greilberger J, Ledinski G, Kager G, Paigen B, Jurgens G. Atherosclerosis. 2004 Feb;172(2):239-46.